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Sub‐centennial oxygen (δ¹⁸O) isotopes of ostracod and authigenic calcite from Squanga Lake provides evidence of hydroclimatic extremes and a series of post‐glacial climate system reorganizations for the interior region of northwest Canada. Authigenic calciteδ¹⁸O values range from −16‰ to −21‰ and are presently similar to modern lake water and annual precipitation values. Ostracodδ¹⁸O record near identical trends with calcite, offset by +1.7 ± 0.6‰. At 11 ka BP (kaBP = thousands of years before 1950), higherδ¹⁸O values reflect decreased precipitation−evaporation (P−E) balance from residual ice sheet influences on moisture availability. A trend to lowerδ¹⁸O values until ∼8 ka BP reflects a shift to wetter conditions, and reorganization of atmospheric circulation. The last millennium and modern era are relatively dry, though not as dry as the early Holocene extreme. North Pacific climate dynamics remained an important driver of P−E balance in northwest Canada throughout the Holocene.

A submillennial‐resolution record of lake water oxygen isotope composition (δ¹⁸O) from chironomid head capsules is presented from Burial Lake, northwest Alaska. The record spans the Last Glacial Maximum (LGM; ~20–16k cal abp) to the present and shows a series of large lake δ¹⁸O shifts (~5‰). Relatively low δ¹⁸O values occurred during a period covering the LGM, when the lake was a shallow, closed‐basin pond. Higher values characterize deglaciation (~16–11.5k cal abp) when the lake was still closed but lake levels were higher. A rapid decline between ~11 and 10.5k cal abpindicates that lake levels rose to overflowing. Lake δ¹⁸O values are interpreted to reflect the combined effects of changes in lake hydrology, growing season temperature and meteoric source water as well as large‐scale environmental changes impacting this site, including opening of the Bering Strait and shifts in atmospheric circulation patterns related to ice‐sheet dynamics. The results indicate significant shifts in precipitation minus evaporation across the late Pleistocene to early Holocene transition, which are consistent with temporal patterns of vegetation change and paludification. This study provides new perspectives on the paleohydrology of eastern Beringia concomitant with human migration and major turnover in megafaunal assemblages.